General Notes
This product (Catalog No. DPABH-28518) is a rabbit-derived polyclonal antibody raised against human WNT2, targeting the amino acid region 231–270 of the protein. This antibody exhibits cross-reactivity with Human WNT2 from mouse and rat. It has been affinity purified by Protein A. Wnt2 is a secreted glycoprotein that is one of the canonical Wnt ligands. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Wnt2 is known to directly regulate β-catenin activity, the key player in proliferation and inflammation. Recently, studies have demonstrated that Wnt2 is overexpressed in various human cancers, including esophageal, gastric, colorectal, breast, lung, cervical, and malignant glioma.
DPABH-28518 is suitable for use in Western blot (WB) (1:500–1:1,000), IHC (1:50–1:500), IF/ICC (1:50–1:500), flow cytometry (FC) (0.40 μg per 10^6 cells in a 100 μl suspension) applications.
DPABH-28518 is supplied as a liquid formulation in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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