Anti-WWOX monoclonal antibody Made to order

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

A synthetic peptide of human WWOX is used for rabbit immunization.

Conjugate

Alternative Names

WWOX; WW domain containing oxidoreductase; WW domain-containing oxidoreductase; FOR; SDR41C1; short chain dehydrogenase/reductase family 41C; member 1; WOX1; WW domain-containing protein WWOX; fragile site FRA16D oxidoreductase; short chain dehydrogenase/

Entrez Gene ID

UniProt ID

Antigen Description

WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD). The highest normal expression of this gene is detected in hormonally regulated tissues such as testis, ovary, and prostate. This expression pattern and the presence of an SRD domain suggest a role for this gene in steroid metabolism. The encoded protein is more than 90% identical to the mouse protein, which is an essential mediator of tumor necrosis factor-alpha-induced apoptosis, suggesting a similar, important role in apoptosis for the human protein. In addition, there is evidence that this gene behaves as a suppressor of tumor growth. Alternative splicing of this gene generates transcript variants that encode different isoforms.

Pathway

ErbB4 signaling events, organism-specific biosystem; Nuclear signaling by ERBB4, organism-specific biosystem; Signal Transduction, organism-specific biosystem; Signaling by ERBB4, organism-specific biosystem;