Synthetic peptide corresponding to a region within C terminal amino acids 343-392 (TPPAPPSREA SRPPEEPSAP SPTLPTQFKQ RAPMYNSGLS PATPAPAAPT) of Mouse WHSC2 (NP_036044).
Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. Probably required to interact with the RNA polymerase II complex.
Pathway
Formation of RNA Pol II elongation complex; Formation of the Early Elongation Complex; Gene Expression; RNA Polymerase II Pre-transcription Events; RNA Polymerase II Transcription; RNA Polymerase II Transcription Elongation;
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