Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. Probably required to interact with the RNA polymerase II complex.
Pathway
Abortive elongation of HIV-1 transcript in the absence of Tat; Disease; Formation of HIV-1 elongation complex containing HIV-1 Tat; Formation of HIV-1 elongation complex in the absence of HIV-1 Tat; Formation of RNA Pol II elongation complex; Formation of
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