Synthetic peptide: AVEYSDSEDDSEFDEVDWLE conjugated to KLH, corresponding to C terminal amino acids 540-559 of Human WAVE 1
Conjugate
Unconjugated
Applications
Application Notes
WB: Use at a concentration of 0.2 - 0.4 μg/ml. Detects a band of approximately 75 kDa (predicted molecular weight: 62 kDa). Staining of the WAVE band is specifically inhibited with the immunizing peptide.
Target
Alternative Names
WASF1; WAS protein family, member 1; WAVE; SCAR1; WAVE1; wiskott-Aldrich syndrome protein family member 1; protein WAVE-1; WASP family protein member 1; homology of dictyostelium scar 1; verprolin homology domain-containing protein 1;
Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
Pathway
Adherens junction; Bacterial invasion of epithelial cells; E2F transcription factor network; Fc gamma R-mediated phagocytosis
Citations
Publication ()
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