Specifications
Species Reactivity
Mouse; Rat; Human
Immunogen
Synthetic peptide, corresponding to amino acids 477-498 of Human WAVE 1 (Q92558).
Applications
Application Notes
IHC-P: 0.1 - 1 μg/ml; IHC-Fr: 0.1 - 1 μg/ml; ICC: 0.1 - 1 μg/ml.
Target
Alternative Names
WASF1; WAS protein family, member 1; wiskott-Aldrich syndrome protein family member 1; KIAA0269; SCAR1; WAVE; WAVE1; protein WAVE-1; WASP family protein member 1; homology of dictyostelium scar 1; verprolin homology domain-containing protein 1; FLJ31482;
Product Background
Antigen Description
Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
Pathway
Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Bacterial invasion of epithelial cells, organism-specific biosystem; Bacterial invasion of epithelial cells, conserved biosystem; E2F transcription factor network, organism-specific biosystem; Fc gamma R-mediated phagocytosis, organism-specific biosystem; Fc gamma R-mediated phagocytosis, conserved biosystem;
Citations
Publication ()
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COA
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