Anti-CHMP3 monoclonal antibody Made to order

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

A synthetic peptide of human VPS24 is used for rabbit immunization.

Conjugate

Alternative Names

CHMP3; charged multivesicular body protein 3; NEDF; VPS24; CGI-149; 25.1 protein; CHMP family, member 3; chromatin-modifying protein 3; vacuolar protein sorting 24 homolog; neuroendocrine differentiation factor; vacuolar protein sorting-associated protein

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a protein that sorts transmembrane proteins into lysosomes/vacuoles via the multivesicular body (MVB) pathway. This protein, along with other soluble coiled-coil containing proteins, forms part of the ESCRT-III protein complex that binds to the endosomal membrane and recruits additional cofactors for protein sorting into the MVB. This protein may also co-immunoprecipitate with a member of the IFG-binding protein superfamily. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ring finger protein 103 (RNF103) gene.

Pathway

Budding and maturation of HIV virion; Disease; ESCRT-III complex; ESCRT-III complex; Endocytosis; Endocytosis; Endosomal Sorting Complex Required For Transport (ESCRT); HIV Infection; HIV Life Cycle; Internalization of ErbB1; Late Phase of HIV Life Cycle;