Anti-UTRN (aa 3328-3433) polyclonal antibody

Species Reactivity

Human

Immunogen

UTRN (NP_009055, 3328 a.a. ~ 3433 a.a) partial recombinant protein with GST tag. The sequence is LEARMQILEDHNKQLESQLHRLRQLLEQPESDSRINGVSPWASPQHSALSYSLDPDASGP QFHQAAGEDLLAPPHDTSTDLTEVMEQIHSTFPSCCPNVPSRPQAM

Conjugate

Alternative Names

UTRN; utrophin; DRP; DMDL; DRP1; DRP-1; dystrophin-related protein 1;

Entrez Gene ID

UniProt ID

Antigen Description

This gene shares both structural and functional similarities with the dystrophin gene. It contains an actin-binding N-terminus, a triple coiled-coil repeat central region, and a C-terminus that consists of protein-protein interaction motifs which interact with dystroglycan protein components. The protein encoded by this gene is located at the neuromuscular synapse and myotendinous junctions, where it participates in post-synaptic membrane maintenance and acetylcholine receptor clustering. Mouse studies suggest that this gene may serve as a functional substitute for the dystrophin gene and therefore, may serve as a potential therapeutic alternative to muscular dystrophy which is caused by mutations in the dystrophin gene. Alternative splicing of the utrophin gene has been described; however, the full-length nature of these variants has not yet been determined.