USP14 (NP_005142, 395 a.a. ~ 494 a.a) partial recombinant protein with GST tag. The sequence is PQKEVKYEPFSFADDIGSNNCGYYDLQAVLTHQGRSSSSGHYVSWVKRKQDEWIKFDDDK VSIVTPEDILRLSGGGDWHIAYVLLYGPRRVEIMEEESEQ
This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Mice with a mutation that results in reduced expression of the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to 10 weeks of age. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
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A: DPAB-DC3723 antibody store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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