Anti-UQCRB monoclonal antibody Made to order

Name: Anti-UQCRB monoclonal antibody
SKU: DCABH-201685
Rating: 5 (1 reviews)

Rabbit anti-Human UQCRB monoclonal antibody for ICC/IF, IHC-P, IP, WB

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COA

SDS

Datasheet

Summary

Specifications

Antibody Isotype

IgG

Species Reactivity

Mouse; Rat; Human

Immunogen

A synthetic peptide of human UQCRB is used for rabbit immunization.

Conjugate

Unconjugated

Target

Alternative Names

UQCRB; ubiquinol-cytochrome c reductase binding protein; QPC; QCR7; QP-C; UQBC; UQBP; UQPC; UQCR6; MC3DN3; cytochrome b-c1 complex subunit 7; complex III subunit 7; complex III subunit VII; mitochondrial ubiquinone-binding protein; ubiquinol-cytochrome c

Entrez Gene ID

7381

UniProt ID

P14927

Product Background

Antigen Description

This gene encodes a subunit of the ubiquinol-cytochrome c oxidoreductase complex, which consists of one mitochondrial-encoded and 10 nuclear-encoded subunits. The protein encoded by this gene binds ubiquinone and participates in the transfer of electrons when ubiquinone is bound. This protein plays an important role in hypoxia-induced angiogenesis through mitochondrial reactive oxygen species-mediated signaling. Mutations in this gene are associated with mitochondrial complex III deficiency. Alternatively spliced transcript variants have been found for this gene. Related pseudogenes have been identified on chromosomes 1, 5 and X.

Pathway

Alzheimers disease; Cardiac muscle contraction; Cytochrome bc1 complex; Electron Transport Chain; Huntingtons disease;Metabolism; Non-alcoholic fatty liver disease (NAFLD); Non-alcoholic fatty liver disease (NAFLD);Oxidative phosphorylation; Parkinsons disease; Respiratory electron transport;

Citations

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Documents

pdf COA

pdf SDS

pdf Datasheet

QA & Reviews

Customer Reviews

References

Functional inhibition of UQCRB suppresses angiogenesis in zebrafish

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Authors: Cho, Yoon Sun; Jung, Hye Jin; Seok, Seung Hyeok; Payumo, Alexander Y.; Chen, James K.; Kwon, Ho Jeong

Abstract

As a subunit of mitochondrial complex III, UQCRB plays an important role in complex III stability, electron transport, and cellular oxygen sensing. Herein, we report UQCRB function regarding angiogenesis in vivo with the zebrafish (Danio rerio). UQCRB knockdown inhibited angiogenesis in zebrafish leading to the suppression of VEGF expression. Moreover, the UQCRB-targeting small molecule terpestacin also inhibited angiogenesis and VEGF levels in zebrafish, supporting the role of UQCRB in angiogenesis. Collectively, UQCRB loss of function by either genetic and pharmacological means inhibited angiogenesis, indicating that UQCRB plays a key role in this process and can be a prognostic marker of angiogenesis- and mitochondria-related diseases. (C) 2013 Elsevier Inc. All rights reserved.

Synthesis, spectroscopic characterization (FT-IR, FT-Raman, and NMR), quantum chemical studies and molecular docking of 3-(1-(phenylamino)ethylidene)-chroman-2,4-dione

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

Authors: Avdovic, Edina H.; Milenkovic, Dejan; Markovic, Jasmina M. Dimitric; Dorovic, Jelena; Vukovic, Nenad; Vukic, Milena D.; Jevtic, Verica V.; Trifunovic, Srecko R.; Potocnak, Ivan; Markovic, Zoran

Abstract

The experimental and theoretical investigations of structure of the 3-(1-(phenylamino)ethylidene)-chroman2,4-dione were performed. X-ray structure analysis and spectroscopic methods (FTIR and FT-Raman, H-1 and C-13 NMR), along with the density functional theory calculations (B3LYP functional with empirical dispersion corrections D3BJ in combination with the 6-311 + G(d,p) basis set), were used in order to characterize the molecular structure and spectroscopic behavior of the investigated coumarin derivative. Molecular docking analysis was carried out to identify the potency of inhibition of the title molecule against human's Ubiquinol-Cytochrome C Reductase Binding Protein (UQCRB) and Methylenetetrahydrofolate reductase (MTHFR). The inhibition activity was obtained for ten conformations of ligand inside the proteins. (C) 2018 Elsevier B.V. All rights reserved.