Anti-UGT2B4 monoclonal antibody, clone FQS22788

Antibody Isotype

IgG

Clone

FQS22788

Species Reactivity

Human

Immunogen

Synthetic peptide within Human UGT2B4 aa 500 to the C-terminus. The exact sequence is proprietary.Database link: P06133

Conjugate

Application Notes

WB: 1/1000 - 1/100000; IP: 1/10 - 1/100;

Alternative Names

UGT2B4; UDP glucuronosyltransferase 2 family, polypeptide B4; UDP glycosyltransferase 2 family, polypeptide B4; UDP-glucuronosyltransferase 2B4; UGT2B11; UDPGTh-1; UDPGT 2B4; hyodeoxycholic acid; UDP glucuronosyltransferase 2B4; hyodeoxycholic acid-specif

Entrez Gene ID

UniProt ID

Antigen Description

The UDP-Glucuronosyltransferases (UGT) comprise a family of enzymes that detoxify and enhance the urinary excretion of a wide variety of xenobiotic and endogenous substrates by transferring glucuronic acid to sulfhydryl, hydroxyl, aromatic amino, or carboxylic acid groups. They have been subdivided into two families, UGT1 and UGT2, based on the evolutionary divergence of their genes. The enzymes of the UGT1A family play an important role in the metabolism of dietary constituents, phenols, and therapeutic drugs, and also the glucuronidation of bilirubin and iodothyronines. The enzymes of the UGT2B family are involved in the metabolism of bile acids, phenol derivatives, catecholestrogens and steroids. Although it is widely recognized that the liver is the major site of glucuronidation, it is now clear that UGT enzymes are also found in extra-hepatic tissues.

Pathway

Ascorbate and aldarate metabolism, organism-specific biosystem; Ascorbate and aldarate metabolism, conserved biosystem; Ascorbate biosynthesis, animals, glucose-1P => ascorbate, organism-specific biosystem; Ascorbate biosynthesis, animals, glucose-1P => ascorbate, conserved biosystem; Bile secretion, organism-specific biosystem;