Anti-UFD1L monoclonal antibody, clone FQS23958

Antibody Isotype

IgG

Clone

FQS23958

Species Reactivity

Mouse; Rat; Human

Immunogen

Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human UFD1L aa 1-100 (N terminal). The exact sequence is proprietary.Database link: Q92890

Conjugate

Application Notes

WB: 1/1000 - 1/10000; ICC/IF: 1/50 - 1/100; Flow Cyt: 1/30.

Alternative Names

UFD1L; ubiquitin fusion degradation 1 like (yeast); ubiquitin fusion degradation 1 like; ubiquitin fusion degradation protein 1 homolog; UFD1; UB fusion protein 1;

Entrez Gene ID

UniProt ID

Antigen Description

Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures.

Pathway

HRD1/SEL1 ERAD complex, organism-specific biosystem; HRD1/SEL1 ERAD complex, conserved biosystem; Protein processing in endoplasmic reticulum, organism-specific biosystem; Protein processing in endoplasmic reticulum, conserved biosystem; p97-Ufd1-Npl4 complex, organism-specific biosystem.