Anti-UFD1L (aa 1-277) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Recombinant protein fragment corresponding to a region within amino acids 1 and 277 of UFD1L (NP_005650; UniProt ID: Q92890 isoform short).

Conjugate

Application Notes

WB: 1/500 - 1/3000; IHC-P: 1/100 - 1/500; ICC/IF: 1/100 - 1/200.

Alternative Names

UFD1L; ubiquitin fusion degradation 1 like (yeast); ubiquitin fusion degradation 1 like; ubiquitin fusion degradation protein 1 homolog; UFD1; UB fusion protein 1;

Entrez Gene ID

UniProt ID

Antigen Description

Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures.

Pathway

HRD1/SEL1 ERAD complex; Protein processing in endoplasmic reticulum; p97-Ufd1-Npl4 complex;