Anti-UCP3 monoclonal antibody, clone FQS7538

Antibody Isotype

IgG

Clone

FQS7538

Conjugate

Application Notes

WB: 1:1,000 - 10,000; IP: 1:10 - 100; Flow Cyt: 1:10 - 100

Alternative Names

UCP3; uncoupling protein 3 (mitochondrial, proton carrier); mitochondrial uncoupling protein 3; SLC25A9; UCP 3; Uncoupling protein-3; solute carrier family 25 member 9;

Entrez Gene ID

UniProt ID

Antigen Description

Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. The different UCPs have tissue-specific expression; UCP3 is primarily expressed in skeletal muscle. It is postulated to protect mitochondria against lipid-induced oxidative stress. Expression levels of UCP3 increase when fatty acid supplies to mitochondria exceed their oxidation capacity, and the protein enables the export of fatty acids from mitochondria. UCPs contain the three solcar protein domains typically found in MACPs.

Pathway

Diurnally regulated genes with circadian orthologs, organism-specific biosystem; Electron Transport Chain, organism-specific biosystem; Energy Metabolism, organism-specific biosystem; Metabolism, organism-specific biosystem; Mitochondrial Uncoupling Proteins, organism-specific biosystem; Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins., organism-specific biosystem; The citric acid (TCA) cycle and respiratory electron transport, o