Anti-UBTF (aa 55-650) polyclonal antibody

Species Reactivity

Human

Immunogen

UBTF (NP_055048, 551 a.a. ~ 650 a.a) partial recombinant protein with GST tag. The sequence is PPAATNSSKKMKFQGEPKKPPMNGYQKFSQELLSNGELNHLPLKERMVEIGSRWQRISQS QKEHYKKLAEEQQKQYKVHLDLWVKSLSPQDRAAYKEYIS

Conjugate

Alternative Names

UBTF; upstream binding transcription factor, RNA polymerase I; UBF; UBF1; UBF2; UBF-1; NOR-90; nucleolar transcription factor 1; autoantigen NOR-90; 90-kDa nucleolus organizer region autoantigen;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a member of the HMG-box DNA-binding protein family. The encoded protein plays a critical role in ribosomal RNA transcription as a key component of the pre-initiation complex, mediating the recruitment of RNA polymerase I to rDNA promoter regions. The encoded protein may also play important roles in chromatin remodeling and pre-rRNA processing, and its activity is regulated by both phosphorylation and acetylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3, 11 and X and the long arm of chromosome 11.

Pathway

Epigenetic regulation of gene expression; Negative epigenetic regulation of rRNA expression; RNA Polymerase I Chain Elongation; RNA Polymerase I Promoter Escape