Anti-UBE2H monoclonal antibody, clone T3

Antibody Isotype

IgG2a

Clone

T3

Species Reactivity

Human

Immunogen

UBE2H (AAH06277, 1 a.a. ~ 183 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Conjugate

Alternative Names

UBE2H; ubiquitin-conjugating enzyme E2H; ubiquitin conjugating enzyme E2H (homologous to yeast UBC8) , ubiquitin conjugating enzyme E2H (UBC8 homolog, yeast); ubiquitin-conjugating enzyme E2 H; UBC8; UBCH; ubiquitin-protein ligase H; ubiquitin carrier pro

Entrez Gene ID

UniProt ID

Antigen Description

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein sequence is 100% identical to the mouse homolog and 98% identical to the frog and zebrafish homologs. Two alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms.

Pathway

Adaptive Immune System, organism-specific biosystem; Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem; Class I MHC mediated antigen processing & presentation, organism-specific biosystem; Immune System, organism-specific biosystem; Ubiquitin mediated proteolysis, organism-specific biosystem.