Synthetic peptide corresponding to internal sequence amino acids 470-482 (isoform 1) and 432-444 (isoform 2) of Human UBASH3A (NP_061834.1; NP_001001895.1).
Conjugate
Unconjugated
Applications
Application Notes
WB: 1 - 3 μg/ml; IHC-P: 3.75 μg/ml.
Target
Alternative Names
UBASH3A; ubiquitin associated and SH3 domain containing A; ubiquitin-associated and SH3 domain-containing protein A; CLIP4; STS 2; TULA; T-cell ubiquitin ligand 1; cbl-interacting protein 4; T-cell ubiquitin ligand protein; suppressor of T-cell receptor s
Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain.
Citations
Publication ()
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COA
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