This gene encodes one of two family members belonging to the T-cell ubiquitin ligand (TULA) family. Both family members can negatively regulate T-cell signaling. This family member can facilitate growth factor withdrawal-induced apoptosis in T cells, which may occur via its interaction with AIF, an apoptosis-inducing factor. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Synonyms
UBASH3A; ubiquitin associated and SH3 domain containing A; ubiquitin-associated and SH3 domain-containing protein A; CLIP4; STS 2; TULA; T-cell ubiquitin ligand 1; cbl-interacting protein 4; T-cell ubiquitin ligand protein; suppressor of T-cell receptor signaling 2; STS-2; TULA-1;
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