Anti-Tropomyosin monoclonal antibody, clone UN-422

Antibody Isotype

IgG1

Clone

UN-422

Species Reactivity

Chicken

Immunogen

Purified chicken gizzard tropomyosin.

Conjugate

Alternative Names

TPM1; tropomyosin 1, alpha; tropomyosin alpha-1 chain; tropomyosin-1; alpha tropomyosin; alpha-tropomyosin; TM2; Tm3; Tmpa; Tpm-1; AA986836; AI854628; alpha-TM;

Entrez Gene ID

UniProt ID

Antigen Description

Tropomyosin is a dimeric coiled coil protein that binds along the length of actin filaments. It is associated with the thin filaments of muscle cells and the microfilaments of nonmuscle cells. Chicken embryo fibroblasts (CEF) contain five isoforms of tropomyosin (a, b, 1, 2, and 3), identified as such by their different apparent molecular masses after separation by SDS-PAGE, but similar biochemical properties, such as resistance to heat and organic solvents, the ability to bind to F actin filaments, and the lack of proline and tryptophan.

Pathway

Cardiac muscle contraction, organism-specific biosystem; Cardiac muscle contraction, conserved biosystem; Dilated cardiomyopathy, organism-specific biosystem; Dilated cardiomyopathy, conserved biosystem; Hypertrophic cardiomyopathy (HCM), organism-specific biosystem; Hypertrophic cardiomyopathy (HCM), conserved biosystem; Striated Muscle Contraction, organism-specific biosystem;