Anti-Thomsen Friedenreich Tn antigen monoclonal antibody (DMAB12477)

Mouse anti-Thomsen Friedenreich Tn antigen monoclonal antibody for IHC, ICC Datasheet

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Host Species
Antibody Isotype
Uo 329
Species Reactivity
Human, Sheep
Asialo ovine submaxillary mucin (AOSM).


Application Notes
Immunohistochemistry (Frozen sections) (1:50-1:100); Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50-1:100) & The optimal working dilution should be determined by the end user.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.


Alternative Names
Tn antigen; Mouse Anti-Thomsen Friedenreich Tn antigen Monoclonal Antibody; Anti-Thomsen Friedenreich Tn antigen Monoclonal Antibody; Thomsen Friedenreich Tn antigen Monoclonal Antibody Mouse Anti-Thomsen Friedenreich Tn antigen MAb; Anti-Thomsen Friedenr

Product Background

Antigen Description
Tn antigen refers to the "oligosaccharide" (in fact monosaccharide) structure N-acetylgalactosamine (GalNAc) linked to serine or threonine by a glycosidic bond, i. e. as an O-glycan. It is not usually found on healthy cell surfaces, but may be found on cancer cells. Addition of single monosaccharide residues creates disaccharide antigens: the Thomsen-Friedenreich antigen (TF antigen or T antigen) is formed by substitution with galactose (Gal(b1-3)GalNAc); the sialyl Tn antigen (STn antigen) is formed by substitution with sialic acid (Neu5Ac(a2-6)GalNAc. Further substitution gives the normal core structures and O-glycans found on healthy cell surfaces.


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Blixt, O; Lavrova, OI; et al. Analysis of Tn antigenicity with a panel of new IgM and IgG1 monoclonal antibodies raised against leukemic cells. GLYCOBIOLOGY 22:529-542(2012).
Yuasa, N; Ogawa, H; et al. Construction and expression of anti-Tn-antigen-specific single-chain antibody genes from hybridoma producing MLS128 monoclonal antibody. JOURNAL OF BIOCHEMISTRY 151:371-381(2012).

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