Anti-Thomsen Friedenreich Tn antigen monoclonal antibody (DMAB12477)
Mouse anti-Thomsen Friedenreich Tn antigen monoclonal antibody for IHC, ICC
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Asialo ovine submaxillary mucin (AOSM).
Immunohistochemistry (Frozen sections) (1:50-1:100); Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50-1:100) & The optimal working dilution should be determined by the end user.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.
Tn antigen; Mouse Anti-Thomsen Friedenreich Tn antigen Monoclonal Antibody; Anti-Thomsen Friedenreich Tn antigen Monoclonal Antibody; Thomsen Friedenreich Tn antigen Monoclonal Antibody Mouse Anti-Thomsen Friedenreich Tn antigen MAb; Anti-Thomsen Friedenr
Tn antigen refers to the "oligosaccharide" (in fact monosaccharide) structure N-acetylgalactosamine (GalNAc) linked to serine or threonine by a glycosidic bond, i. e. as an O-glycan. It is not usually found on healthy cell surfaces, but may be found on cancer cells. Addition of single monosaccharide residues creates disaccharide antigens: the Thomsen-Friedenreich antigen (TF antigen or T antigen) is formed by substitution with galactose (Gal(b1-3)GalNAc); the sialyl Tn antigen (STn antigen) is formed by substitution with sialic acid (Neu5Ac(a2-6)GalNAc. Further substitution gives the normal core structures and O-glycans found on healthy cell surfaces.
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Gaidzik, N; Westerlind, U; et al. The development of synthetic antitumour vaccines from mucin glycopeptide antigens. CHEMICAL SOCIETY REVIEWS 42:4421-4442(2013).
Blixt, O; Lavrova, OI; et al. Analysis of Tn antigenicity with a panel of new IgM and IgG1 monoclonal antibodies raised against leukemic cells. GLYCOBIOLOGY 22:529-542(2012).
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.