Anti-Thomsen Friedenreich Tn antigen monoclonal antibody (DMAB12477)

Mouse anti-Thomsen Friedenreich Tn antigen monoclonal antibody for IHC, ICC Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgM
Clone
Uo 329
Species Reactivity
Human, Sheep
Immunogen
Asialo ovine submaxillary mucin (AOSM).
Conjugate
Unconjugated

Applications


Application Notes
Immunohistochemistry (Frozen sections) (1:50-1:100); Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50-1:100) & The optimal working dilution should be determined by the end user.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
Tn antigen; Mouse Anti-Thomsen Friedenreich Tn antigen Monoclonal Antibody; Anti-Thomsen Friedenreich Tn antigen Monoclonal Antibody; Thomsen Friedenreich Tn antigen Monoclonal Antibody Mouse Anti-Thomsen Friedenreich Tn antigen MAb; Anti-Thomsen Friedenr

Product Background


Antigen Description
Tn antigen refers to the "oligosaccharide" (in fact monosaccharide) structure N-acetylgalactosamine (GalNAc) linked to serine or threonine by a glycosidic bond, i. e. as an O-glycan. It is not usually found on healthy cell surfaces, but may be found on cancer cells. Addition of single monosaccharide residues creates disaccharide antigens: the Thomsen-Friedenreich antigen (TF antigen or T antigen) is formed by substitution with galactose (Gal(b1-3)GalNAc); the sialyl Tn antigen (STn antigen) is formed by substitution with sialic acid (Neu5Ac(a2-6)GalNAc. Further substitution gives the normal core structures and O-glycans found on healthy cell surfaces.

Citations


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References


Yi, B; Zhang, Z; et al. CD176 antiserum treatment leads to a therapeutic response in a murine model of leukemia. ONCOLOGY REPORTS 30:1841-1847(2013).
Mazal, D; Lo-Man, R; et al. Monoclonal antibodies toward different Tn-amino acid backbones display distinct recognition patterns on human cancer cells. Implications for effective immuno-targeting of cancer. CANCER IMMUNOLOGY IMMUNOTHERAPY 62:1107-1122(2013).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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