Anti-Sialosyl-Tn antigen monoclonal antibody (DMAB12476)

Mouse anti-Sialosyl-Tn antigen monoclonal antibody for IHC, ICC, IF, FC Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Species Reactivity
Human, Sheep
Immunogen
Ovine submaxillary mucin (OSM).
Conjugate
Unconjugated

Applications


Application Notes
Immunohistochemistry (1:50-1:100) & The optimal working dilution should be determined by the end user.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
CD175s; Mouse Anti-Sialosyl-Tn antigen Monoclonal Antibody; Anti-Sialosyl-Tn antigen Monoclonal Antibody; Sialosyl-Tn antigen Monoclonal Antibody Mouse Anti-Sialosyl-Tn antigen MAb; Anti-Sialosyl-Tn antigen MAb; Sialosyl-Tn antigen MAb

Product Background


Antigen Description
Sialosyl Tn antigen also known as CD175s is expressed in the majority of colon, gastric, breast and lung carcinoma. The sialosyl Tn has limited expression to being absent in normal colon, pancreas, stomach, ovary, and prostate. This antigen is detected in several adenocarcinomas. It appears to be useful marker for poorly differentiated colon adenocarcinomas. This antibody stains colon carcinomas and ovarian mucinous carcinomas producing apical cytoplasmic, apical membrane or luminal staining patterns. It is negative with majority of adult tissue sections.

Citations


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References


MACLEAN, GD; REDDISH, M; et al. IMMUNIZATION OF BREAST-CANCER PATIENTS USING A SYNTHETIC SIALYL-TN GLYCOCONJUGATE PLUS DETOX ADJUVANT. CANCER IMMUNOLOGY IMMUNOTHERAPY 36:215-222(1993).
Kircheis, R; Vondru, P; et al. Immunization of Rhesus monkeys with the conjugate vaccine IGN402 induces an IgG immune response against carbohydrate and protein antigens, and cancer cells. VACCINE 24:2349-2357(2006).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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