Specifications
Immunogen
Synthetic peptide from the N-terminal region of Human Twist.
Applications
Application Notes
WB: 1/1000 - 1/5000; IHC-P: 1/100 - 1/1000;
Target
Alternative Names
TWIST1; twist homolog 1 (Drosophila); acrocephalosyndactyly 3 , ACS3, blepharophimosis, epicanthus inversus and ptosis 3 , BPES3, TWIST; twist-related protein 1; bHLHa38; BPES2; H twist; Saethre Chotzen syndrome; SCS; H-twist; B-HLH DNA binding protein;
Product Background
Antigen Description
Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation.
Pathway
Adipogenesis, organism-specific biosystem; HIF-2-alpha transcription factor network, organism-specific biosystem; Notch-mediated HES/HEY network, organism-specific biosystem.
Citations
Publication ()
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COA
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