NPRL2 (nitrogen permease regulator-like 2 (S. cerevisiae)) is a protein-coding gene. Diseases associated with NPRL2 include nephrotic syndrome, and lung cancer. GO annotations related to this gene include protein binding and protein kinase activity. Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at the Tyr-9 Tyr-373 and Tyr-376 residues. May act as a tumor suppressor. Suppresses cell growth and enhanced sensitivity to various anticancer drugs.
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