Synthetic peptide: QYSNVYCPTPKV, corresponding to amino acids 240-251 of Human NPR2L (NP_006536.3).
Conjugate
Unconjugated
Applications
Application Notes
Peptide Antibody detection limit dilution: 1/32000. WB: Use at a concentration of 0.1 - 0.3 μg/ml. Detects a band of approximately 45 kDa (predicted molecular weight: 44 kDa).
Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at the Tyr-9 Tyr-373 and Tyr-376 residues. May act as a tumor suppressor. Suppresses cell growth and enhanced sensitivity to various anticancer drugs.
Citations
Publication ()
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