Tubby like protein 4 is a novel gene belonging to the tubby superfamily proteins (TUSP). The protein sequences of these genes are 40-48% identical to other tubby family proteins at the C-terminal conserved 'tubby domain'. The TUSP proteins also contain a tubby signature motif (FXGRVTQ), two bipartite nuclear localization signals (NLSs) at the C-terminal, one WD40 repeat region, one suppressor of cytokines signaling domain and two proline-rich regions. The precise biological function of the tubby superfamily genes is still unknown. However the highly conserved tubby domain in different species suggests that these proteins must have fundamental biological functions in a wide range of multi-cellular organisms.
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