Immunogen
Synthetic peptide: C-SKVTHIEIRNTRNLT, corresponding to internal sequence amino acids 101-115 of Human TSH Receptor (part of the extracellular domain), with Cysteine residue linker, according to NP_000360.2; NP_001018046.1.
Alternative Names
TSHR; thyroid stimulating hormone receptor; LGR3; CHNG1; hTSHR-I; thyrotropin receptor; thyrotropin receptor-I, hTSHR-I; seven transmembrane helix receptor; thyroid stimulating hormone receptor, isoform 2;
Antigen Description
The TSH receptor, a G protein coupled seven transmembrane receptor, is present on the basal surface of thyroid follicular cells. It is involved in regulating thyrocyte cell growth and function by mediating thyroid stimulating hormone (TSH) action. The TSH receptor is also the target autoantigen in autoimmune thyroid diseases. Autoantibodies to the TSH receptor that stimulate cAMP production in thyrocyte cells, called thyroid stimulating antibodies, are responsible for the hyperthyroidism of Graves Disease. Another class of autoantibodies that block the binding of TSH to the TSH receptor, thyroid blocking antibodies, may mediate the hypothyroidism associated with Hashimotos thyroiditis, primary myxoedema, and neonatal hypothyroidism. Studies indicate that these autoantibodies interact primarily with the extracellular region of the TSH receptor. TSH receptor expression has been reported in adipose, adrenal, brain, eye, heart, kidney, skin, thymus, and thyroid. ESTs have been isolated from brain, placenta, and thyroid libraries.
COA
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