Specifications
Immunogen
Recombinant protein corresponding to the extracellular region of human TSHR.
Applications
Application Notes
Immunohistochemistry (1:10-1:50) & The optimal working dilution should be determined by the end user.
Target
Alternative Names
thyroid stimulating hormone receptor; MGC75129; LGR3; Thyroid-stimulating hormone receptor; seven transmembrane helix receptor; TSH-R; thyrotropin receptor; CHNG1; hTSHR-I; thyrotropin receptor-I, hTSHR-I; thyroid stimulating hormone receptor, isoform 2
Product Background
Antigen Description
The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene.
Mouse monoclonal antibody raised against partial recombinant TSHR.
Pathway
Arf6 signaling events, organism-specific biosystem; Arf6 trafficking events, organism-specific biosystem; Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (s) signalling events, organism-specific biosystem
Citations
Publication ()
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COA
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