Anti-TSG101 (aa 2-20) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide: AVSESQLKKMVSKYKYRDL conjugated to KLH, corresponding to N terminal amino acids 2-20 of Human TSG101

Conjugate

Application Notes

WB: 1 - 2 μg/ml.

Alternative Names

TSG101; tumor susceptibility gene 101; TSG10, tumor susceptibility gene 10; tumor susceptibility gene 101 protein; VPS23; tumor susceptibility protein; ESCRT-I complex subunit TSG101; TSG10;

Entrez Gene ID

UniProt ID

Antigen Description

Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses.

Pathway

Assembly of HIV virion; Disease; ESCRT-I complex; Endocytosis; Endosomal Sorting Complex Required For Transport (ESCRT); Glucocorticoid receptor regulatory network;