Recombinant human TRPM2 protein; Source: E. coli derived, PGEX-4T; Tag: GST; Domain: 1217-1553 aa of BC112342
Conjugate
Unconjugated
Applications
Application Notes
IHC: 1:50-1:500 IF-P: 1:50-1:500
General Notes
This product (Catalog No. DPABH-18819) is a rabbit-derived polyclonal antibody raised against human TRPM2, targeting the amino acid region 1217–1553 of the protein. This antibody exhibits cross-reactivity with Human TRPM2 from mouse. It has been affinity purified by Protein A. Nonselective, voltage-independent cation channel mediating sodium and calcium ion influx in response to oxidative stress. Extracellular calcium passes through the channel and acts from the intracellular side as a positive regulator in channel activation. Activated by ADP-ribose, nicotinamide adenine dinucleotide (NAD(+)), reactive nitrogen species and arachidonic acid. Inactivated by intracellular ATP. Confers susceptibility to cell death following oxidative stress. Isoform 2 does not seem to be regulated by ADPR. Has ADP-ribose pyrophosphatase activity. DPABH-18819 is suitable for use in IHC (1:50–1:500), IF-P (1:50–1:500) applications. DPABH-18819 is supplied as a liquid formulation in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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