Anti-TRIM5 (aa 50-150) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide conjugated to KLH derived from within residues 50 - 150 of Human TRIM5 alpha.

Conjugate

Application Notes

WB: 1 μg/ml. IHC-P: 1 μg/ml.

Alternative Names

TRIM5; tripartite motif containing 5; RNF88; TRIM5alpha; tripartite motif-containing protein 5; ring finger protein 88; tripartite motif protein TRIM5; tripartite motif containing 5 transcript variant iota; tripartite motif containing 5 transcript variant

Entrez Gene ID

UniProt ID

Antigen Description

Isoform Alpha is a retrovirus restriction factor, which mediates species-specific, early block to retrovirus infection. Targets retroviral capsid soon after entry into the cell, and prevents reverse transcription of the virus RNA genome. Isoform Alpha trimers may make multiple contacts with the hexameric lattice of CA proteins which constitute the surface of retrovirion core, and somehow inactivate the virus. Restricts efficiently infection by N-MLV, but not HIV-1. May have E3 ubiquitin-protein ligase activity.