Anti-TPR (aa 1-98) polyclonal antibody

Species Reactivity

Human

Immunogen

TPR (NP_003283, 1 a.a. ~ 98 a.a) partial recombinant protein with GST tag. The sequence is MAAVLQQVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKR LSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKE

Conjugate

Alternative Names

TPR; translocated promoter region, nuclear basket protein; nucleoprotein TPR; megator; tumor potentiating region; NPC-associated intranuclear protein; translocated promoter region protein; nuclear pore complex-associated protein TPR; translocated promoter

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a large coiled-coil protein that forms intranuclear filaments attached to the inner surface of nuclear pore complexes (NPCs). The protein directly interacts with several components of the NPC. It is required for the nuclear export of mRNAs and some proteins. Oncogenic fusions of the 5 end of this gene with several different kinase genes occur in some neoplasias.

Pathway

Antiviral mechanism by IFN-stimulated genes; Cell Cycle, Mitotic; Disease; Gene Expression