Specifications
Species Reactivity
Chicken
Immunogen
Full length native Tropomyosin 1 (alpha) purified from chicken embryo fibroblasts (CEF) and chicken leg, heart, and gizzard.
Target
Alternative Names
TPM1; tropomyosin 1, alpha; tropomyosin alpha-1 chain; tropomyosin 3 alpha; hepatoma alpha tropomyosin; smooth muscle alpha-tropomyosin; striated muscle alpha-tropomyosin; Tma2; Tmsa; Alpha-tm;
Product Background
Antigen Description
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.
Pathway
Cardiac muscle contraction, organism-specific biosystem; Cardiac muscle contraction, conserved biosystem; Dilated cardiomyopathy, organism-specific biosystem; Dilated cardiomyopathy, conserved biosystem; Hypertrophic cardiomyopathy (HCM), organism-specific biosystem; Hypertrophic cardiomyopathy (HCM), conserved biosystem; Striated Muscle Contraction, organism-specific biosystem;
Citations
Publication ()
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COA
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