Rabbit Anti-Human TPM1 (a.a. 201-284) Polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human; Mouse; Rat; Dog; Zebrafish; Sheep

Immunogen

KLH conjugated synthetic peptide derived from human Tropomyosin: 201-284/284

Conjugate

Application Notes

IHC-P: 1:100-500
IHC-F: 1:100-500
IF: 1:100-500

General Notes

This product (Catalog No. DPABH-16503) is a rabbit-derived IgG polyclonal antibody raised against human TPM1, targeting the amino acid region 201–284 of the protein. This antibody exhibits cross-reactivity with TPM1 from mouse, rat, dog, zebrafish, and sheep. It has been affinity purified by Protein A. This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy and dilated cardiomyopathy 1Y.
DPABH-16503 is suitable for use in IHC-P (1:100–1:500), IHC-F (1:100–1:500), IF (immunofluorescence) (1:100–1:500) applications.
DPABH-16503 is supplied as a liquid formulation in 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Alternative Names

Tropomyosin 1 (alpha); Alpha tropomyosin; Alpha-tropomyosin; C15orf13; cardiomyopathy, hypertrophic 3; CMD1Y; CMH3; HTM alpha; sarcomeric tropomyosin kappa; TMSA; TPM1; TPM1_HUMAN; Tropomyosin 1; Tropomyosin1; Tropomyosin alpha 1 chain; Tropomyosin alpha-1 chain; Tropomyosin-1; Tropomyosin α; Tropomyosin-α; Tropomyosinα

Entrez Gene ID

UniProt ID