Anti-TNKS monoclonal antibody (CAB-4906MH)

Mouse anti-TNKS monoclonal antibody for ELISA, WB, IHC Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Clone
2B3
Species Reactivity
Human
Immunogen
TNKS (NP_003738, 1017 a.a. ~ 1125 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Applications


Application Notes
WB: 1:500-1000
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
TNKS; tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase; tankyrase-1; PARP 5a; PARP5A; pART5
Entrez Gene ID
UniProt ID

Product Background


Antigen Description
Tankyrase-1 is an enzyme that in humans is encoded by the TNKS gene. 0The function about TNKS antigen include NAD+ ADP-ribosyltransferase activity; metal ion binding; protein binding; transferase activity, transferring glycosyl groups; zinc ion binding.
Pathway
Regulation of Telomerase, organism-specific biosystem.

Citations


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References


Kuimov, AN; Kuprash, DV; et al. Cloning and characterization of TNKL, a member of tankyrase gene family. GENES AND IMMUNITY 2:52-55(2001).
Shebzukhov, YV; Lavrik, IN; et al. Human tankyrases are aberrantly expressed in colon tumors and contain multiple epitopes that induce humoral and cellular immune responses in cancer patients. CANCER IMMUNOLOGY IMMUNOTHERAPY 57:871-881(2008).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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