Anti-TNK2 (N-terminal) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide conjugated to KLH, corresponding to a region within the N terminus of Human ACK1 (UniProt Q07912).

Conjugate

Application Notes

WB: 1/50 - 1/100; IHC-P: 1/50 - 1/100; Flow Cyt: 1/10 - 1/50; ICC/IF: 1 μg/ml;

Alternative Names

TNK2; tyrosine kinase, non-receptor, 2; ACK; ACK1; ACK-1; p21cdc42Hs; activated CDC42 kinase 1; activated p21cdc42Hs kinase; activated Cdc42-associated kinase 1; tyrosine kinase non-receptor protein 2;

Entrez Gene ID

UniProt ID

Antigen Description

Non-receptor tyrosine kinase that regulates the activity of a number of proteins by tyrosine phosphorylation especially proteins critical for cell survival, cell growth, and proliferation. Activates AKT1 by phosphorylating it on Tyr-176 resulting in its activation. Phosphorylates AR on Tyr-267 and Tyr-363 and promotes its recruitment to the androgen-responsive enhancers (AREs). Phosphorylates WWOX on Tyr-287. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR. Participates in clathrin-mediated endocytosis. May be involved both in adult synaptic function and plasticity and in brain development.

Pathway

CDC42 signaling events; Focal Adhesion;