Anti-TNK2 monoclonal antibody Made to order

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

A synthetic peptide of human TNK2 is used for rabbit immunization.

Conjugate

Alternative Names

TNK2; tyrosine kinase, non-receptor, 2; activated CDC42 kinase 1; ACK; ACK1; activated Cdc42 associated kinase 1; p21cdc42Hs; activated p21cdc42Hs kinase; activated Cdc42-associated kinase 1; tyrosine kinase non-receptor protein 2; ACK-1; FLJ44758; FLJ455

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined.

Pathway

CDC42 signaling events, organism-specific biosystem; EGFR1 Signaling Pathway, organism-specific biosystem; Focal Adhesion, organism-specific biosystem; G13 Signaling Pathway, organism-specific biosystem;