Anti-TNFAIP3 (aa 483-790) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Recombinant protein fragment, corresponding to a region within amino acids 483-790 of Human TNFAIP3 (Uniprot ID P21580)

Conjugate

Application Notes

WB: 1/500 - 1/3000.

Alternative Names

TNFAIP3; tumor necrosis factor, alpha-induced protein 3; tumor necrosis factor alpha-induced protein 3; A20; OTUD7C; TNFAIP3 (A20); zinc finger protein A20; TNF alpha-induced protein 3; OTU domain-containing protein 7C; putative DNA-binding protein A20; t

Entrez Gene ID

UniProt ID

Antigen Description

Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Upon TNF stimulation, deubiquitinates Lys-63-polyubiquitin chains on RIPK1 and catalyzes the formation of Lys-48-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. In vitro able to deubiquitinate both Lys-48- and Lys-63 polyubiquitin chains. Inhibitor of programmed cell death. Has a role in the function of the lymphoid system.

Pathway

CD40/CD40L signaling; Canonical NF-kappaB pathway; Immune System; Innate Immune System; Measles; NOD-like receptor signaling pathway;