Anti-TLR9 (aa 26-300) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Recombinant fragment, corresponding to a region within amino acids 26-300 of Human TLR9.

Conjugate

Application Notes

WB: 1/500 - 1/3000; IHC-P: 5 μg/ml.

Alternative Names

TLR9; toll-like receptor 9; CD289;

Entrez Gene ID

UniProt ID

Antigen Description

Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.

Pathway

African trypanosomiasis; Chagas disease (American trypanosomiasis); Herpes simplex infection; IRS-mediated signalling;