Specifications
Species Reactivity
Mouse; Dog; Human
Immunogen
Purified fusion protein of extracellular domain of human TLR9 (AA 1-815) and human IgGFc
Applications
Application Notes
IHC-P: 1/50; WB: 1/50; IHC-Fr: 1/50; Flow Cyt: 1/50; ICC/IF: 1/50.
Target
Alternative Names
TLR9; toll-like receptor 9; CD289;
Product Background
Antigen Description
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
Pathway
African trypanosomiasis, organism-specific biosystem; African trypanosomiasis, conserved biosystem; Chagas disease (American trypanosomiasis), organism-specific biosystem; Chagas disease (American trypanosomiasis), conserved biosystem; Herpes simplex infection, organism-specific biosystem; Herpes simplex infection, conserved biosystem; IRS-mediated signalling, organism-specific biosystem;
Citations
Publication ()
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COA
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