Synthetic peptide within Mouse TLR8 aa 965-995 (C terminal) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.Database link: P58682
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
Pathway
Immune System; Innate Immune System; MyD88 dependent cascade initiated on endosome; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling; TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation; Toll Like Receptor 7/8 (TLR7/8) Casc
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