Anti-TLR8 monoclonal antibody, clone 55D254 [PE]

Antibody Isotype

IgG1

Clone

55D254

Species Reactivity

Mouse; Human

Immunogen

This antibody was developed against a KLH-conjugated synthetic peptide of human TLR8, within amino acids 750-850.

Conjugate

Application Notes

WB: 1 - 3 μg/ml; Flow Cyt: 2-5μg/10⁶ cells;

Alternative Names

TLR8; toll-like receptor 8; CD288; MGC119599; MGC119600;

Entrez Gene ID

UniProt ID

Antigen Description

Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.

Pathway

Immune System, organism-specific biosystem; Innate Immune System, organism-specific biosystem; MyD88 dependent cascade initiated on endosome, organism-specific biosystem; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling, organism-specific biosystem; TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, organism-specific biosystem; Toll Like Receptor 7/8 (TLR7/8) Cascade, organism-specific biosystem; Toll Like Receptor 9 (TLR9) Cascade, organism-specific biosystem;