This gene encodes a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development. Expression of this gene has been associated with a favorable outcome to chemotherapy with taxanes for ovarian carcinoma. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.
Pathway
Disease; FBXW7 Mutants and NOTCH1 in Cancer; NOTCH1 Intracellular Domain Regulates Transcription; Signal Transduction; Signaling by NOTCH; Signaling by NOTCH1; Signaling by NOTCH1 HD Domain Mutants in Cancer; Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer; Signaling by NOTCH1 PEST Domain Mutants in Cancer; Signaling by NOTCH1 in Cancer; Signaling by NOTCH1 t(7.
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