Anti-TLE3 monoclonal antibody (DCABH-201589) Made to order

Rabbit anti-Human TLE3 monoclonal antibody for WB, ELISA

View other TLE3 antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human TLE3 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
TLE3; transducin-like enhancer of split 3; ESG; ESG3; GRG3; HsT18976
Entrez Gene ID
UniProt ID

Product Background


Gene summary
TLE3 (Transducin Like Enhancer Of Split 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by NOTCH1. An important paralog of this gene is AES. This gene encodes a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development. Expression of this gene has been associated with a favorable outcome to chemotherapy with taxanes for ovarian carcinoma. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.
Antigen Description
This gene encodes a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development. Expression of this gene has been associated with a favorable outcome to chemotherapy with taxanes for ovarian carcinoma. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity). Transducin-like enhancer protein 3 is a protein that in humans is encoded by the TLE3 gene. 0The function about TLE3 antigen include protein binding.
Pathway
Disease; FBXW7 Mutants and NOTCH1 in Cancer; NOTCH1 Intracellular Domain Regulates Transcription; Signal Transduction; Signaling by NOTCH; Signaling by NOTCH1; Signaling by NOTCH1 HD Domain Mutants in Cancer; Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer; Signaling by NOTCH1 PEST Domain Mutants in Cancer; Signaling by NOTCH1 in Cancer; Signaling by NOTCH1 t(7.

Citations


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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Wulbeck, C; CamposOrtega, JA; et al. Two zebrafish homologues of the Drosophila neurogenic gene groucho and their pattern of transcription during early embryogenesis. DEVELOPMENT GENES AND EVOLUTION 207:156-166(1997).
Kulkarni, SA; Hicks, DG; et al. TLE3 as a candidate biomarker of response to taxane therapy. BREAST CANCER RESEARCH 11:-(2009).

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