Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.
Pathway
Delta-Notch Signaling Pathway; FBXW7 Mutants and NOTCH1 in Cancer; Notch-mediated HES/HEY network; Regulation of Wnt-mediated beta catenin signaling and target gene transcription
Citations
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