Anti-TLE1 monoclonal antibody, clone 2G6

Antibody Isotype

IgG2a

Clone

2G6

Species Reactivity

Human

Immunogen

Recombinant fragment, corresponding to amino acids 180-460 of Human TLE 1 produced in E.coli (NP_005068).

Conjugate

Application Notes

WB: 1/2000; IHC-P: 1/150; Flow Cyt: 1/100; ICC/IF: 1/100;

Alternative Names

TLE1; transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila); transducin like enhancer of split 1, homolog of Drosophila E(sp1); transducin-like enhancer protein 1; enhancer of split groucho 1; ESG; ESG1; GRG1; e(Sp1) homolog; enhancer of split

Entrez Gene ID

UniProt ID

Antigen Description

Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.

Pathway

Delta-Notch Signaling Pathway, organism-specific biosystem; NOTCH1 Intracellular Domain Regulates Transcription, organism-specific biosystem; Notch-mediated HES/HEY network, organism-specific biosystem; Presenilin action in Notch and Wnt signaling, organism-specific biosystem; Regulation of Wnt-mediated beta catenin signaling and target gene transcription, organism-specific biosystem; Signal Transduction, organism-specific biosystem; Signaling by NOTCH, organism-specific biosystem;