Anti-THUMPD1 monoclonal antibody (DCABH-4725)

Mouse anti-Human THUMPD1 monoclonal antibody for WB, IHC-P, ICC/IF

Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
2I7
Species Reactivity
Mouse, Human, Monkey
Immunogen
Recombinant full length Human THUMPD1 produced in HEK293T cells (NP_060206)
Conjugate
Unconjugated

Applications


Application Notes
WB: 1/200 - 1/4000; IHC-P: 1/150; ICC/IF: 1/100;
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
THUMPD1; THUMP domain containing 1; THUMP domain-containing protein 1; FLJ20274; DKFZp686C1054
Entrez Gene ID
UniProt ID

Product Background


Antigen Description
This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene.

Citations


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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Armengaud, J; Urbonavicius, J; et al. N-2-methylation of guanosine at position 10 in tRNA is catalyzed by a THUMP domain-containing, S-adenosylmethionine-dependent methyltransferase, conserved in Archaea and Eukaryota. JOURNAL OF BIOLOGICAL CHEMISTRY 279:37142-37152(2004).
Silva, APG; Byrne, RT; et al. Expression, purification, crystallization and preliminary X-ray studies of the TAN1 orthologue from Methanothermobacter thermautotrophicus. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS 64:1083-1086(2008).

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