Anti-THRSP monoclonal antibody (DCABH-13759) Made to order

Rabbit anti-Human THRSP monoclonal antibody for WB, ELISA

View other THRSP antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human THRSP is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
THRSP; thyroid hormone responsive; lipogenic protein 1 , LPGP1, thyroid hormone responsive SPOT14 (rat) homolog; thyroid hormone-inducible hepatic protein; Lpgp; S14
Entrez Gene ID
UniProt ID

Product Background


Gene summary
THRSP (Thyroid Hormone Responsive) is a Protein Coding gene. GO annotations related to this gene include protein homodimerization activity. An important paralog of this gene is MID1IP1. The protein encoded by this gene is similar to the gene product of S14, a rat gene whose expression is limited to liver and adipose tissue and is controlled by nutritional and hormonal factors. This gene has been shown to be expressed in liver and adipocytes, particularly in lipomatous modules. It is also found to be expressed in lipogenic breast cancers, which suggests a role in controlling tumor lipid metabolism.
Antigen Description
The protein encoded by this gene is similar to the gene product of S14, a rat gene whose expression is limited to liver and adipose tissue and is controlled by nutritional and hormonal factors. This gene has been shown to be expressed in liver and adipocytes, particularly in lipomatous modules. It is also found to be expressed in lipogenic breast cancers, which suggests a role in controlling tumor lipid metabolism. Plays a role in the regulation of lipogenesis, especially in lactating mammary gland. Important for the biosynthesis of triglycerides with medium-length fatty acid chains. May modulate lipogenesis by interacting with MID1IP1 and preventing its interaction with ACACA (By similarity). May function as transcriptional coactivator. May modulate the transcription factor activity of THRB. Thyroid hormone-inducible hepatic protein is a protein that in humans is encoded by the THRSP gene. 0The function about THRSP antigen include protein homodimerization activity.

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References


de Arrieta, CM; Morte, B; et al. The human RC3 gene homolog, NRGN contains a thyroid hormone-responsive element located in the first intron. ENDOCRINOLOGY 140:335-343(1999).
Shah, GN; Li, JP; et al. Cloning and characterization of a complementary DNA for a thyroid hormone-responsive protein in mature rat cerebral tissue. BIOCHEMICAL JOURNAL 327:617-623(1997).

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