Transcription factor that specifically recognizes and binds E-box sequences (3-CANNTG-5). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5-GTCACGTGAC-3) present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta.
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
Citations
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Camparo, P; Vasiliu, V; et al. Renal translocation carcinomas - Clinicopathologic, immunohistochemical, and gene expression profiling analysis of 31 cases with a review of the literature. AMERICAN JOURNAL OF SURGICAL PATHOLOGY 32:656-670(2008).
MCLANE, KE; BURTON, DR; et al. TRANSPLANTATION OF A 17-AMINO ACID ALPHA-HELICAL DNA-BINDING DOMAIN INTO AN ANTIBODY MOLECULE CONFERS SEQUENCE-DEPENDENT DNA RECOGNITION. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 92:5214-5218(1995).
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