Anti-TFEB monoclonal antibody, clone T3

Antibody Isotype

IgG1

Clone

T3

Species Reactivity

Human

Immunogen

TFEB (AAH32448, 1 a.a. ~ 476 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Conjugate

Alternative Names

TFEB; transcription factor EB; bHLHe35; TCFEB; T-cell transcription factor EB; class E basic helix-loop-helix protein 35; BHLHE35; ALPHATFEB;

Entrez Gene ID

UniProt ID

Antigen Description

Transcription factor that specifically recognizes and binds E-box sequences (3'-CANNTG-5'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta.