A region within synthetic peptide: SVSTPLIIKW LENISCRDGP FVYGRTQMTL TFQKEVAERL AANTGSKQRS, corresponding to internal sequence amino acids 145-194 of Human TFB1M
S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity.
Pathway
Energy Metabolism; Mitochondrial Gene Expression;
Citations
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