Anti-TERF2IP (aa 100-150) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide corresponding to a region within amino acids 100-150 of Human RAP1 (NP_061848.2).

Conjugate

Application Notes

WB: 1/2000 - 1/10000. IP: 2-10 μg/mg

Alternative Names

TERF2IP; telomeric repeat binding factor 2, interacting protein; RAP1; DRIP5; telomeric repeat-binding factor 2-interacting protein 1; hRap1; RAP1 homolog; TRF2-interacting telomeric protein 1; TERF2-interacting telomeric protein 1; repressor/activator pr

Entrez Gene ID

UniProt ID

Antigen Description

Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5-TTAGGG-3 repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5-TTAGGG-3 sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes.

Pathway

Cell Cycle; Cellular responses to stress; DNA Damage/Telomere Stress Induced Senescence; Meiosis